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Chromatography Resins – CHT™ Ceramic Hydroxyapatite Media
CHT Ceramic Hydroxyapatite Media is an advanced mixed-mode chromatography media engineered to tackle the most challenging biologic purifications. By leveraging calcium affinity with cation exchange properties, it delivers high-resolution separation and remarkable selectivity for your target molecule.
Its ability to simultaneously clear DNA, endotoxins, and host cell proteins in a single step makes it a trusted workhorse for achieving exceptional purity and process efficiency.
Excellent separation capabilities
Efficient column packing capability
Exceptional clearance of aggregates and other impurities
Selection Guide
When selecting the appropriate CHT Ceramic Hydroxyapatite Media type, the size of the molecule to be purified is the primary consideration.
For large molecules, such as viruses or IgMs, CHT Ceramic Hydroxyapatite Type II Media is recommended due to its larger pore size.
If the virus is small enough, CHT Ceramic Hydroxyapatite XT Media may also be suitable. For smaller molecules under 400 kD, like IgGs or recombinant proteins, the isoelectric point becomes the main consideration, where acidic molecules are best purified using CHT Ceramic Hydroxyapatite Type I Media, while neutral or basic molecules are suited for CHT Ceramic Hydroxyapatite XT Media, with CHT Ceramic Hydroxyapatite Type II Media serving as a backup option.
All product images of CHT Ceramic Hydroxyapatite Media and the selection guide are courtesy of Bio-Rad Laboratories, Inc. Hercules, CA, USA and used on this website with permission.
